2. Ed, Edd n Eddy (January 4, 1999 – November 8, 2009)

Ed, Edd n Eddy was created by Danny Antonucci for Cartoon Network. The show centers on three preteen boys named Ed, Edd (called "Double D"), and Eddy—collectively known as "the Eds"—who live in a suburban cul-de-sac in the fictional town of Peach Creek. Under the unofficial leadership of Eddy, the trio frequently invent schemes to make money from their peers to purchase their favorite confectionery, jawbreakers. Their plans usually fail, leaving them in various, often humiliating, predicaments.

The series premiered on January 4, 1999. During the show's run, several specials and shorts were produced in addition to the regular television series. The series concluded with a TV movie, Ed, Edd n Eddy's Big Picture Show, on November 8, 2009. Ed, Edd n Eddy was the longest-running Cartoon Network original series at the time of its end, and maintained the record until December 27, 2016, when the Ben 10 franchise became 11 years old.